职称 副教授
学位 博士
邮箱 xujiezhang@mail.hzau.edu.cn
政治面貌:致公党党员
研究方向 鱼类免疫学与病害防控
教育经历
2012.09-2015.06 中国科学院水生生物研究所理学博士(专业:遗传学)
2009.09-2012.06 中国科学院水生生物研究所理学硕士(专业:水生生物学)
2005.09-2009.06 华中农业大学农学学士(专业:水产养殖)
主要职历
2018.07-至今 51菠菜网,副教授
2017.08-2018.06 上海海洋大学水产与生命学院,讲师
2015.09-2017.07 上海海洋大学水产与生命学院,师资博士后
科研成果
主要研究内容
1. 鱼类B细胞和免疫球蛋白的组成、功能及分化机制
2. 鱼类抗菌多肽的结构、功能、演化及分子设计
3. 鱼用疫苗、免疫佐剂及免疫增强剂的研发
主持和参与的主要科研项目
1. 长江经济带大宗水生生物产业绿色发展教育部工程研究中心项目(2662021SSSY004),2021/01/01-2023/12/31,20万元,主持
2. 国家自然科学基金面上项目(31972824),2020/01-2023/12,58万元,主持
3. 国家重点研发计划蓝色粮仓科技创新专项课题(2018YFD0900503),2018/12-2022/12,45.4万元,子任务主持人
4. 中央高校基本科研业务费专项基金-科研启动经费(2662018QD053),2018/09-2021/09,20万元,主持
5. 国家自然科学基金青年科学基金项目(31602184),2017/01-2019/12,20万元,主持
6. 国家自然科学基金面上项目(31472307),2015/01-2018/12,88万元,参与
7. 国家自然科学基金青年科学基金项目(31101623),2012/01-2014/12,23万元,参与
8. 国家自然科学基金面上项目(31070112),2011/01-2013/12,32万元,参与
9. 企业横向课题(707122105),2022/01/01-2022/12/31,20万元,主持
代表性学术论文
1. Jie Wang, Chang-Song Wu, Ya-Zhen Hu, Lan Yang, Xu-Jie Zhang*, Yong-An Zhang*. Plasmablasts induced by chitosan oligosaccharide secrete natural IgM to enhance the humoral immunity in grass carp. Carbohydrate Polymers, 2022, 281: 119073.
2. Ya-Zhen Hu, Zi-You Ma, Chang-Song Wu, Jie Wang, Yong-An Zhang*, Xu-Jie Zhang*. LECT2 is a novel antibacterial protein in vertebrates. Journal of Immunology, 2022, 208(8): 2100812.
3. Zi-You Ma, Jia-Xin Liang, Wen-Shuo Li, Yuan Sun, Chang-Song Wu, Ya-Zhen Hu, Jun Li, Yong-An Zhang*, Xu-Jie Zhang*. Complement C3a Enhances the Phagocytic Activity of B Cells Through C3aR in a Fish. Frontiers in Immunology, 2022, 13: 873982.
4. Chang‑Song Wu, Zi‑You Ma, Guo‑Dong Zheng, Shu‑Ming Zou, Xu‑Jie Zhang*, Yong‑An Zhang*. Chromosome-level genome assembly of grass carp (Ctenopharyngodon idella) provides insights into its genome evolution. BMC Genomics, 2022, 23: 271.
5. Zheng-Wei Cui, Xiang-Yang Zhang, Chang-Song Wu, Yong-An Zhang, Yang Zhou*, Xu-Jie Zhang*. Membrane IgM+ plasma cells in grass carp (Ctenopharyngodon idella): Insights into the conserved evolution of IgM+ plasma cells in vertebrates. Developmental and Comparative Immunology, 2020, 106: 103613.
6. Zheng-Wei Cui, Xiang-Yang Zhang, Xiao-Hua Chen*, Xu-Jie Zhang*, Yong-An Zhang. Splicing variants of grass carp (Ctenopharyngodon idellus) IL-21: Functions in IgM+ B cell proliferation and IgM secretion. Developmental and Comparative Immunology, 2020, 110: 103728.
7. Xu-Jie Zhang#, Xiang-Yang Zhang#, Peng Wang, Yong-An Zhang*. Identification of another primordial CD80/86 molecule in rainbow trout: Insights into the origin and evolution of CD80 and CD86 in vertebrates. Developmental and Comparative Immunology, 2018, 89: 73-82.
8. Xu-Jie Zhang, Peng Wang, Nu Zhang, Dan-Dan Chen, Pin Nie, Jia-Le Li*, Yong-An Zhang*. B Cell Functions Can Be Modulated by Antimicrobial Peptides in Rainbow Trout Oncorhynchus mykiss: Novel Insights into the Innate Nature of B cells in Fish, Frontiers in Immunology, 2017, 8: 388.
9. Nu Zhang, Xu-Jie Zhang, Dan-Dan Chen, J. Oriol Sunyer, Yong-An Zhang*. Molecular characterization and expression analysis of three subclasses of IgT in rainbow trout (Oncorhynchus mykiss). Developmental and Comparative Immunology, 2017, 70: 94-105.
10. Long-Feng Lu, Shun Li, Xiao-Bing Lu, Scott E LaPatra, Nu Zhang, Xu-Jie Zhang, Dan-Dan Chen, Pin Nie, Yong-An Zhang*. Spring Viremia of Carp Virus N Protein Suppresses Fish IFN1 Production by Targeting the Mitochondrial Antiviral Signaling Protein. Journal of Immunology, 2016, 196: 3744-3753.
11. Nu Zhang, Xu-Jie Zhang, Yu-Long Song, Xiao-Bing Lu, Dan-Dan Chen, Xiao-Qin Xia, J. Oriol Sunyer, Yong-An Zhang*. Preferential combination between the light and heavy chain isotypes of fish immunoglobulins. Developmental and Comparative Immunology, 2016, 61:169-179.
12. Xia Guo, Dan-Dan Chen, Kai-Song Peng, Zheng-Wei Cui, Xu-Jie Zhang, Shun Li, Yong-An Zhang*. Identification and characterization of Bacillus subtilis from grass carp (Ctenopharynodon idellus) for use as probiotic additives in aquatic feed. Fish Shellfish Immunology, 2016, 52: 74-84.
13. Xu-Jie Zhang, Xiang-Yang Zhang, Nu Zhang, Xia Guo, Kai-Song Peng, Han Wu, Long-Feng Lu, Nan Wu, Dan-Dan Chen, Shun Li, Pin Nie, Yong-An Zhang*. Distinctive Structural Hallmarks and Biological Activities of the Multiple Cathelicidin Antimicrobial Peptides in a Primitive Teleost Fish. Journal of Immunology, 2015, 194(10): 4974-4987.
14. Xu-Jie Zhang, Wu-Ming Yang, Han Wu, Xiao-Ning Gong, Ai-Hua Li*. Multilocus sequence typing revealed a clonal lineage of Aeromonas hydrophila caused motile Aeromonas septicemia outbreaks in pond-cultured cyprinid fish in an epidemic area in central China. Aquaculture, 2014, 432: 1-6.
15. Xu-Jie Zhang, Wu-Ming Yang, De-Feng Zhang, Tong-Tong Li, Xiao-Ning Gong, Ai-Hua Li*. Does the gastrointestinal tract serve as the infectious route of Aeromonas hydrophila in crucian carp (Carassius carassius)? Aquaculture Research, 2013, 46(1): 141-154.